Searchable abstracts of presentations at key conferences in endocrinology

ea0029p1780 | Thyroid cancer | ICEECE2012

CLM94, a novel cyclic amide with anti-VEGFR-2 and antiangiogenic properties, is active against primary anaplastic thyroid cancer in vitro and in vivo

Antonelli A. , Bocci G. , La Motta C. , Ferrari S. , Fallahi P. , Ruffilli I. , Di Domenicantonio A. , Da Settimo F. , Miccoli P.

Introduction: The antitumor activity of a novel cyclic amide, CLM94, with anti-VEGFR-2 and antiangiogenic activity, in primary anaplastic thyroid cancer (ATC) cells in vitro and in vivo, has been studied.Design and Methods: CLM94 was tested: i) in two human cell lines (HMVEC-d, dermal microvascular endothelial cells; 8305C, undifferentiated thyroid cancer) at 0.001–100 mcM; ii) in ATC cells at the concentrations of 10, 30, 50 mcM; iii)...

ea0029p125 | Adrenal medulla | ICEECE2012

Pheochromocytoma incidentally discovered after thyroid surgery manifesting dramatic hypertensive crisis induced by metoclopramide

Corsello S. , Ricciato M. , Paragliola R. , Bello G. , Bocci M. , De Crea C. , Raffaelli M. , Lombardi C. , Antonelli M. , Pontecorvi A. , Bellantone R.

Introduction: Metoclopramide is known to exert stimulatory effects on catecholamine secretion, having been used in the past as provocative test in the diagnosis of pheochromocytoma. We describe a patient with an incidentally discovered pheochromocytoma after metoclopramide administration.Case report: A 64 years-old woman underwent total thyroidectomy for multinodular goiter with ‘follicular proliferation Thy 3’ at FNAB of the target nodule. The...